There's such a ridiculously abundant number of ways to boost an individual character's power in the series at this point that the answer to this question is "of course".
Find more of that Super God Water, learn the Kaioken, wish back the Namekian Grand Elder and have him unlock their potential, cybernetic enhancements ala 17 and 18, wish back Babidi and have him unlock their potential, have the Elder Kaioshin unlock their potential, learn Fusion, use the Potara, train with Whis, start using weapons like Sorbet's laser, and likely several others that I'm forgetting.
The real question, would they bother? Probably not, unfortunately.
Granted, this is talking strictly about relevance in a "winning fights" sort of way. They've stayed plenty relevant, in a "serves a useful purpose" sort of way, even in Resurrection F (stalling, communication, healer roles, etc).